BMS-986176

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AAK1-IN-1 是一种高度选择性且有效的接头相关激酶 1 (AAK1，IC50 = 2 nM) 抑制剂。

AAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).(In Vitro):AAK1-IN-1can be used for neurodegenerative disease studies. Adaptor associated kinase 1 (AAK1) is a member of the Arkl/Prkl family of serine/threonine kinases and modulates clatherin coated endocytosis. and receptor-mediated endocytosis.

Adaptor associated kinase 1 (AAK1) is a member of the Arkl/Prkl family of serine/threonine kinases. AAKl mRNA exists in two splice forms termed short and long. The long form predominates and is highly expressed in brain and heart. AAKl is enriched in synaptosomal preparations and is co-localized with endocytic structures in cultured cells. AAKl modulates clatherin coated endocytosis, a process that is important in synaptic vesicle recycling and receptor-mediated endocytosis.

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LX-9211 | AAK1-IN-1

Others

Other Targets

Antifungal

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1815613-42-3

385.4

C19H23F4N3O

>98% (HPLC)

In Vitro:?DMSO : 220 mg/mL (570.84 mM)

N/A

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(-20℃)

With Ice Pack

≥ 2 years