PF-1355

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PF-1355 是一种基于 2-硫氧嘧啶机制的选择性 MPO 抑制剂。 PF-1355用于治疗血管炎疾病。

PF-1355 is a selective 2-thiouracil mechanism-based MPO inhibitor. PF-1355 is used for treatment of vasculitic diseases.(In Vitro):PF-1355 inhibits MPO activity in phorbol ester-stimulated human neutrophils as measured by taurine chlorination (EC50=1.47 μM) as well as lipopolysaccharide-treated human blood measuring residual MPO activity (EC50=2.03 μM) .(In Vivo):Oral administration of PF-1355 reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevates circulating cytokines. In a model of anti-glomerular basement membrane disease, albuminuria and chronic renal dysfunction are completely suppressed by PF-1355 treatment .

In a dose-responsive fashion, PF-1355 inhibits MPO activity in phorbol ester-stimulated human neutrophils as measured by taurine chlorination (EC50=1.47 μM) as well as lipopolysaccharide-treated human blood measuring residual MPO activity (EC50=2.03 μM).

Oral administration of PF-1355 reduces plasma MPO activity, vascular edema, neutrophil recruitment, and elevates circulating cytokines. In a model of anti-glomerular basement membrane disease, formerly known as Good pasture disease, albuminuria and chronic renal dysfunction are completely suppressed by PF-1355 treatment.

PF-06281355 | PF 06281355 | ZINC205721785

Others

Other Targets

Antifungal

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1435467-38-1

321.35

C14H15N3O4S

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (155.59 mM)

O=C1C=C(C=2C=C(OC)C=CC2OC)N(C(=S)N1)CC(=O)N

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(-20℃)

With Ice Pack

≥ 2 years