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Fosifloxuridine nafalbenamide
CAS No. 1332837-31-6
Fosifloxuridine nafalbenamide ( NUC-3373 | NUC 3373 | NUC3373 | Fosifloxuridine nafalbenamide )
产品货号. M28004 CAS No. 1332837-31-6
NUC-3373 (Fosifloxuridine nafalbenamide) 是一种嘧啶核苷酸类似物，是一种胸苷酸合酶抑制剂。NUC-3373 具有抗癌活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1568 | 有现货 |
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| 10MG | ￥2204 | 有现货 |
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| 25MG | ￥3841 | 有现货 |
|
| 50MG | ￥5375 | 有现货 |
|
| 100MG | ￥7317 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥2119 | 有现货 |
|
生物学信息
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产品名称Fosifloxuridine nafalbenamide
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述NUC-3373 (Fosifloxuridine nafalbenamide) 是一种嘧啶核苷酸类似物，是一种胸苷酸合酶抑制剂。NUC-3373 具有抗癌活性。
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产品描述NUC-3373 (Fosifloxuridine nafalbenamide), a pyrimidine nucleotide analogue, is a Thymidylate synthase inhibitor.NUC-3373 has anticancer activity. NUC-3373 is a ProTide transformation of 5-FU that generates much higher concentrations of FUDR-MP in patients' cells.
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体外实验Fosifloxuridine nafalbenamide induces the release of damage-associated molecular patterns (DAMPs), with increased expression of calreticulin (CRT) at the cell surface and concomitant loss of nuclear nuclear high mobility group box protein 1 (HMGB1).
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体内实验Fosifloxuridine nafalbenamide exhibits anti-cancer activity in HT-29 nude mouse xenograft models.
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同义词NUC-3373 | NUC 3373 | NUC3373 | Fosifloxuridine nafalbenamide
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通路Cell Cycle/DNA Damage
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靶点DNA/RNA Synthesis
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受体hLigI
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研究领域——
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适应症——
化学信息
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CAS Number1332837-31-6
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分子量631.55
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分子式C29H30F2N4O8P
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (162.99 mM)
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SMILESC[C@H](N[P](O)(=O)(OC[C@H]1O[C@@H](n2ccc(N)nc2=O)C(F)(F)[C@@H]1O)c1cccc2ccccc12)C(=O)OCc1ccccc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Howes TRL, et al. Structure-activity relationships among DNA ligase inhibitors: Characterization of a selective uncompetitive DNA ligase I inhibitor. DNA Repair (Amst). 2017 Dec;60:29-39.
产品手册
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