MOMIPP

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

MOMIPP 是 PIKfyve 抑制剂和巨胞饮诱导剂。 MOMIPP 很容易穿透血脑屏障，并且在抑制脑内胶质母细胞瘤异种移植物的进展方面具有中等效果。

MOMIPP is a PIKfyve inhibitor and a macropinocytosis inducer. MOMIPP readily penetrates the blood-brain barrier and is moderately effective in suppressing progression of intracerebral glioblastoma xenografts.(In Vitro):MOMIPP can induce intense macropinocytosis, leading to methuosis in cultured glioblastoma cells at low micromolar concentrations. MOMIPP(3 μM) induces cell vacuolization in U373 and Hs683 cell lines. The cytotoxic IPP compound, MOMIPP, causes early disruptions of glucose uptake and glycolytic metabolism. Coincident with these metabolic changes, MOMIPP selectively activates the JNK1/2 stress kinase pathway, resulting in phosphorylation of c-Jun, Bcl-2 and Bcl-xL.(In Vivo):MOMIPP (80?mg/kg; i.p.; once daily; for 15 consecutive days) shows result that MOMIPP is moderately effective in suppressing progression of intracerebral glioblastoma xenografts.

Western Blot Analysis Cell Line:U251 cells Concentration:10?μM Incubation Time:4?h or 24?h Result:Activated the JNK stress kinase pathway.

Animal Model:Athymic CrTac:NCR-Foxn1 mice (female, 7-8?weeks)Dosage:80?mg/kg.Administration:i.p.;once daily; for 15 consecutive days Result:Suppressed progression of intracerebral glioblastoma xenografts.

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PI3K/Akt/mTOR signaling

PI3K

SOS1

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1363421-46-8

292.338

C18H16N2O2

>98% (HPLC)

In Vitro:?DMSO : 31.25 mg/mL (106.90 mM)

COc1ccc2[nH]c(C)c(\C=C\C(=O)c3ccncc3)c2c1

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(-20℃)

With Ice Pack

≥ 2 years