Leteprinim ( AIT 082 acid | AIT-082 acid | AIT082 acid )

产品货号. M27992 CAS No. 138117-50-7

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

Leteprinim
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

Leteprinim 是一种次黄嘌呤衍生物，可刺激体外神经突生长以及星形胶质细胞产生腺苷和神经营养素。
产品描述

Leteprinim is an hypoxanthine derivative that stimulates in vitro neurite outgrowth and the production of adenosine and neurotrophins from astrocytes.(In Vitro):Leteprinim stimulates the outgrowth of neurites from PC12 cells and neurons, stimulates the synthesis and/or release of neurotrophic factors from astrocytes, enhances nerve fibre regeneration in vivo, and enhances memory in animals and humans. Leteprinim also protects against glutamate neurotoxicity in vitro and in vivo, which has led to successful tests of Leteprinim in animal models of acute central nervous system injury.(In Vivo):Leteprinim (60 mg/kg/day; i.p., for 7 days, starting from 20 min before the kainate injection) did not modify the seizures caused by kainate but, like diazepam, it decreased kainate-induced mortality, the reduction of GAD activity, and the loss of hippocampal neurons in rats.
体外实验

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体内实验

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同义词

AIT 082 acid | AIT-082 acid | AIT082 acid
通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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1.BURSTEIN CL. Benzquinamide:cardiovascular stimulant useful during general anesthesia. Anesth Analg. 1963 Jul-Aug;42:429-34.

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