Dimethindene ( Dimetindene | Dimetindeno )

产品货号. M27978 CAS No. 5636-83-9

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

Dimethindene
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

二甲基丁基是一种抗组胺/抗胆碱能化合物。
产品描述

Dimethylbutyl is an antihistamine/anticholinergic drug. It is administered orally and used to relieve itching locally.(In Vitro):In follicle-enclosed Xenopus oocytes, Dimethindene (5-500 μM) decreases Cromakalim cromakalim-induced K+ currents (IC50 = 29.5 μM).(In Vivo):In C57BL/6 mice with skin wound healing, Dimethindene (0.25 mg; i.p.) impairs cutaneous wound healing and delays skin wound closure.
体外实验

Dimethindene (5-500 μM; follicle-enclosed Xenopus oocytes) decreases Cromakalim cromakalim-induced K+ currents with an IC50 value of 29.5 μM.
体内实验

Dimethindene (0.25 mg; i.p.; once; C57BL/6 mice with skin WH) impaires cutaneous wound healing (WH) and delays skin wound closure. Animal Model:C57BL/6 mice with skin WH Dosage:0.25 mg Administration: intraperitoneal injection; once Result:Delayed skin wound closure as compared to vehicle treated mice.
同义词

Dimetindene | Dimetindeno
通路

Others
靶点

Other Targets
受体

Hedgehog|Apoptosis
研究领域

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适应症

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1.Officioso A, et al. Triggering of Erythrocyte Death by Triparanol. Toxins (Basel). 2015 Aug 24;7(8):3359-71.

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