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VU0453595
CAS No. 1432436-13-9
VU0453595 ( VU-0453595 | VU 0453595 )
产品货号. M27939 CAS No. 1432436-13-9
VU0453595 是一种 M1 正变构调节剂 (PAM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥318 | 有现货 |
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| 5MG | ￥523 | 有现货 |
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| 10MG | ￥923 | 有现货 |
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| 25MG | ￥1776 | 有现货 |
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| 50MG | ￥2604 | 有现货 |
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| 100MG | ￥3528 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥568 | 有现货 |
|
生物学信息
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产品名称VU0453595
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述VU0453595 是一种 M1 正变构调节剂 (PAM)。
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产品描述VU0453595 is a M1 positive allosteric modulator (PAM).
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体外实验Application of M1 PAM VU0453595 (3 μM) induces a transient increase in excitability of medium spiny neurons (MSNs).
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体内实验VU0453595 potentiates M1-mediated muscarinic long-term depression (mLTD).VU0453595 (1-10?mg/kg; i.p.) reverses behavioral deficits induced by repeated phencyclidine (PCP) administration. Animal Model:Male C57BL6/J mice (8-9 weeks old)Dosage:1, 3, or 10?mg/kg Administration:Intraperitoneal (i.p.); 10?mL/kg; administered 30?min before the social interaction test Result:Rescued deficits in social interaction observed in PCP-treated mice.
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同义词VU-0453595 | VU 0453595
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通路Cell Cycle/DNA Damage
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靶点AChR
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number1432436-13-9
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分子量322.343
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分子式C18H15FN4O
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 100 mg/mL (310.23 mM)
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SMILESCn1cc(cn1)-c1ccc(CN2Cc3ncccc3C2=O)c(F)c1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Scott DE, et al. Small-molecule inhibitors that target protein-protein interactions in the RAD51 family of recombinases. ChemMedChem. 2015 Feb;10(2):296-303.
产品手册
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