VU0152099

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

VU0152099 是一种有效的选择性 M4 mAChR 变构增强剂 (EC50 = 380 ± 93 nM)。

VU0152099 is a potent and selective M4 mAChR allosteric potentiator(EC50 = 380 ± 93 nM).

VU0152099 (30 μM) induces a dose-dependent leftward shift of the acetylcholine (ACh) concentration response curve (CRC) with maximal shifts of 30-fold observed with 30 μM. VU0152099 dose-dependently potentiates the response to an EC20 concentration of ACh with EC50 values of 1.2 μM, and increases the maximal response to ACh to approximately 130%. VU0152099 is a potent positive allosteric modulator that enhance the response of the M4 receptor to the endogenous agonist ACh.

VU0152099 (56.6 mg/kg; i.p.; once) reverses Amphetamine-induced hyperlocomotion in rats. Animal Model:Male Sprague-Dawley rats (270-300 g) injected with Amphetamine Dosage:56.6 mg/kg .Administration:i.p.; once Result:Reversed Amphetamine-induced hyperlocomotion in rats.

VU 0152099 | VU-0152099

Cell Cycle/DNA Damage

AChR

S1P

——

——

612514-42-8

355.41

C18H17N3O3S

>98% (HPLC)

In Vitro:?DMSO : 12.5 mg/mL (35.17 mM)

Cc1cc(C)c2c(N)c(sc2n1)C(=O)NCc1ccc2OCOc2c1

——

(-20℃)

With Ice Pack

≥ 2 years