Sepin-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Sepin-1 是分离酶的非竞争性抑制剂，IC50 为 14.8 μM。 Sepin-1可以通过抑制细胞增殖和诱导细胞凋亡来抑制小鼠和人类癌细胞系中乳腺癌异种移植肿瘤的生长。

Sepin-1 is a noncompetitive inhibitor of separase with an IC50 of 14.8 μM. Sepin-1 can inhibit the growth of breast cancer xenograft tumors in mice and human cancer cell lines by inhibiting cell proliferation and inducing apoptosis.

Cell Proliferation Assay Cell Line:BT-474, MCF7, MDA-MB-231, MDA-MB-468 cells Concentration:0-64 μM Incubation Time:3 days Result:Inhibited cell growth with EC50s of 18.03, 17.66, 27.33, 27.92 μM for BT-474, MCF7, MDA-MB-231, MDA-MB-468 cells, respectively.Western Blot Analysis Cell Line:BT-474, MCF7, MDA-MB-231, MDA-MB-468 cells Concentration:0, 10, 20, 40 μM Incubation Time:24 h Result:Decreased the expression of FoxM1 protein in a dose-dependent manner, and decreased teh expression of A-Raf, B-Raf, and C-Raf.

Animal Model:SCID beige mice (MCF7 xenografts)Dosage:10 mg/kg Administration:I.v.; daily for 5 days a week for 3 weeks Result:Inhibited tumor growth.

Sepin 1 | Sepin1 | 2H-Benzimidazole, 2,2-dimethyl-5-nitro-, 1,3-dioxide

Others

Other Targets

Endogenous Metabolite

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163126-81-6

223.188

C9H9N3O4

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (448.05 mM)

CC1(C)[N+]([O-])=c2ccc(cc2=[N+]1[O-])[N+]([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years