Dehydroepiandrosterone sulfate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Prasterone硫酸盐是一种HSD11B1表达抑制剂。

Prasterone sulfate is a HSD11B1 expression inhibitor.(In Vitro):Dehydroepiandrosterone sulfate selectively increases the length of neurites containing the dendritic marker MAP-2 and increases neuronal excitability when directly applied to septal-preoptic neurons.(In Vivo):Chronic administration of Dehydroepiandrosterone sulfate produces a dose-dependent effect on performance. In male Sprague-Dawley rats, Dehydroepiandrosterone sulfate (5-20 mg/kg; s.c.) is significantly effective in improving latency to reach the platform.

——

Animal Model:Sixty-four male Sprague-Dawley rats, approximately 90 days of age (300-400 g).Dosage:5, 10, or 20 mg/kg.Administration:Subcutaneous injection starting 7 days post-surgery and 1 h prior to all behavioral testing.Result:Significantly effective in improving latency to reach the platform as compared to injured rats receiving vehicle.

Prasterone sulfate | PB-005 | PB005 | PB 005 | DHEA sulfate | DHEAS |

Others

Other Targets

FLT3

——

——

651-48-9

368.49

C19H28O5S

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (271.38 mM)

[H][C@@]12CCC(=O)[C@@]1(C)CC[C@@]1([H])[C@@]2([H])CC=C2C[C@H](CC[C@]12C)OS(O)(=O)=O

——

(-20℃)

With Ice Pack

≥ 2 years