ML 154 ( NCGC84 )

产品货号. M27660 CAS No. 1345964-89-7

COA

Datasheet

HNMR

HPLC

MSDS

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产品名称

ML 154
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

ML 154 是一种有效的神经肽 S 受体 (NPSR) 拮抗剂。
产品描述

ML 154 is a potent neuropeptide S receptor (NPSR) antagonist.
体外实验

Western Blot Analysis Cell Line:CHO cells expressing NPSR Concentration:0.001 μM, 0.01 μM, 0.1 μM, 1 μM Incubation Time:30 min Result:Exhibited the most potent inhibition on NPS-induced ERK phosphorylation.
体内实验

Animal Model:Male Wistar rats (300-350 g) injected with alcohol Dosage:1 mg/kg (10% Solutol, 10% N,N-dimethylacetamide, and 80% 10 mM PBS, pH 7.4) Administration:Intraperitoneal injection; once Result:Inhibited alcohol-induced central ERK phosphorylation in vivo.
同义词

NCGC84
通路

GPCR/G Protein
靶点

Neuropeptide Y Receptor
受体

G2019S LRRK2
研究领域

——
适应症

——

1.Garofalo AW, et al. Selective Inhibitors of G2019S-LRRK2 Kinase Activity. J Med Chem. 2020 Dec 10;63(23):14821-14839.

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