JW 67

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

JW 67 是经典 Wnt 通路信号传导的抑制剂。 JW 67 迅速减少活性 β-连环蛋白，随后下调 Wnt 靶基因，包括 AXIN2、SP5 和 NKD1。

JW 67 is an inhibitor of canonical Wnt pathway signaling. JW 67 rapidly reduced active β-catenin with a subsequent downregulation of Wnt target genes, including AXIN2, SP5, and NKD1.(In Vitro):JW 67 inhibits the canonical?Wnt?signaling with an?IC50?of 1.17μM. JW 67 (1 μM) increased concentration of AXIN2 and decreased the active form of β-catenin. JW 67 (10 or 25μM) reduced growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S.

JW67 (1 μM; 24 hours) increases concentration of AXIN2 and decreases the active form of β-catenin.JW67 affects the expression of Wnt target genes and reduces cell growth of colon cancer cell lines.JW67 shows a concentration dependent reduction in proliferation with a GI50 value of 7.8 μM. Western Blot Analysis Cell Line:SW480 cells Concentration:1 μM Incubation Time:24 hours Result:Increased the AXIN2 expression.RT-PCR Cell Line:SW480 cells Concentration:10 or 25μM Incubation Time:72 hours Result:Reduced growth of SW480 CRC cells in vitro by inhibiting cell-cycle progression at the G1/S.

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JW67

Wnt/Notch/Hedgehog

Wnt/beta/catenin

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442644-28-2

394.383

C21H18N2O6

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (126.78 mM)

O=C1Nc2ccccc2C11OCC2(CO1)COC1(OC2)C(=O)Nc2ccccc12

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(-20℃)

With Ice Pack

≥ 2 years