CYM 50769 ( —— )

产品货号. M27619 CAS No. 1421365-63-0

COA

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HNMR

HPLC

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产品名称

CYM 50769
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CYM 50769 是一种神经肽 W/B 受体 1 (NPBWR1、GPR7) 拮抗剂 (IC50 = 0.12 μM)。
产品描述

CYM 50769 is a neuropeptide W/B receptor 1 (NPBWR1, GPR7) antagonist(IC50 = 0.12 μM). CYM 50769 inhibited NPW activation of NPBWR1 with a submicromolar IC50, and displayed high selectivity against a broad array of off-targets with pharmaceutical relevance.
体外实验

CYM 50769 (1 and 3 μM; 30 min) attenuates the NPW-23-induced ATDC5 cell proliferation in a dose-dependent manner. Cell Proliferation Assay Cell Line:ATDC5 (exposed with 200 ng/mL NPW-23 for 24 h)Concentration:1 and 3 μM Incubation Time:30 min Result:Attenuated the NPW-23-induced cell proliferation in a dose-dependent manner.
体内实验

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通路

Others
靶点

Other Targets
受体

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研究领域

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适应症

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1.Monteiro JP, et al. Toxicity of methoprene as assessed by the use of a model microorganism. Toxicol In Vitro. 2005;19(7):951-956.

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