CID 5951923

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

CID 5951923 是 KLF5 转录因子的抑制剂，IC50 为 603 nM。

CID 5951923 is an inhibitor of KLF5 transcription factor with an IC50 of 603 nM.(In Vitro):CID 5951923 (10 μM) inhibits the proliferation of cancer cell lines mainly in highly expressing KLF5 cells. CID 5951923 (0.001, 0.01, 0.1, 1, 10, 100 μM) inhibits proliferation of DLD-1 cells in a dose-dependent manner. CID 5951923 (10 μM) significantly decreases endogenous KLF5 levels in the DLD-1 cells, downregulates EGR1, and increases phosphorylation levels of pEGFFpY1068.

CID 5951923 (1 nM-100 μM; 48 h) inhibits proliferation of DLD-1 cells in a dose-dependent manner.CID 5951923 (10 μM; 24 h) significantly decreases endogenous KLF5 levels in the DLD-1 cells, increases phosphorylation levels of pEGFFpY1068, and downregulated EGR1.CID 5951923 (10 μM) inhibits proliferation of cancer cell lines mainly in highly express KLF5 cells. Cell Viability Assay Cell Line:DLD-1 and IEC-6 cells Concentration:0.001, 0.01, 0.1, 1, 10, 100 μM Incubation Time:48 h Result:Inhibited proliferation of DLD-1 cells with an IC50 of 1.6 μM.

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Cell Cycle/DNA Damage

DNA/RNA Synthesis

ROCK2

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749872-43-3

382.39

C16H18N2O7S

>98% (HPLC)

In Vitro:?DMSO : 10 mg/mL (26.15 mM)

CN([C@H]1CCS(=O)(=O)C1)C(=O)COC(=O)\C=C\c1cccc(c1)[N+]([O-])=O

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(-20℃)

With Ice Pack

≥ 2 years