7-Hydroxycarbostyril ( 3,4-Dihydro-7-hydroxycarbostyril )

产品货号. M27524 CAS No. 70500-72-0

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

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产品名称

7-Hydroxycarbostyril
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

7-羟基喹诺酮（3,4-二氢-7-羟基喹诺酮）是一种医药中间体。
产品描述

7-Hydroxycarbostyril (3,4-Dihydro-7-hydroxycarbostyril) is a kind of pharmaceutical intermediate.(In Vitro):?VPC-80051 as the first small molecule inhibitor of hnRNP A1 splicing activity discovered to date by using a computer-aided drug discovery approach. The inhibitor was developed to target the RNA-binding domain (RBD) of hnRNP A1. Further experimental evaluation demonstrated that VPC-80051 interacts directly with hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line. This study lays the groundwork for future structure-based development of more potent and selective small molecule inhibitors of hnRNP A1?RNA interactions aimed at altering the production of cancer-specific alternative splice isoforms.
体外实验

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体内实验

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同义词

3,4-Dihydro-7-hydroxycarbostyril
通路

Others
靶点

Other Targets
受体

TRPA1
研究领域

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适应症

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1.Takaya J, et al. A Potent and Site-Selective Agonist of TRPA1. J Am Chem Soc. 2015 Dec 23;137(50):15859-64.

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