7-Hydroxycarbostyril

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

7-羟基喹诺酮（3,4-二氢-7-羟基喹诺酮）是一种医药中间体。

7-Hydroxycarbostyril (3,4-Dihydro-7-hydroxycarbostyril) is a kind of pharmaceutical intermediate.(In Vitro):?VPC-80051 as the first small molecule inhibitor of hnRNP A1 splicing activity discovered to date by using a computer-aided drug discovery approach. The inhibitor was developed to target the RNA-binding domain (RBD) of hnRNP A1. Further experimental evaluation demonstrated that VPC-80051 interacts directly with hnRNP A1 RBD and reduces AR-V7 messenger levels in 22Rv1 CRPC cell line. This study lays the groundwork for future structure-based development of more potent and selective small molecule inhibitors of hnRNP A1?RNA interactions aimed at altering the production of cancer-specific alternative splice isoforms.

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3,4-Dihydro-7-hydroxycarbostyril

Others

Other Targets

TRPA1

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70500-72-0

161.16

C9H7NO2

>98% (HPLC)

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Oc1ccc2ccc(O)nc2c1

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(-20℃)

With Ice Pack

≥ 2 years