SM-7368

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

NF-κB 激活抑制剂 III 控制 NF-κB 的生物活性。它主要用于炎症/免疫学应用。

The NF-κB Activation Inhibitor III, controls the biological activity of NF-κB. It is primarily used for Inflammation/Immunology applications.

SM-7368 (5 μM) targets downstream of MAPK p38 activation in the human colon derived crypt like HT-29 and Caco-2 epithelial cell lines.SM-7368 inhibits TNF-α-induced MMP-9 upregulation in a concentration-dependent manner and shows maximal activity at 10 μM. SM-7368 inhibits TNF-α-induced MMP-9 mRNA transcript accumulation and protein expression. SM-7368 strongly inhibits TNF-α-induced NF-κB activity but not AP-1 activity. SM-7368 strongly inhibits the TNF-α-induced invasion of HT1080 human fibrosarcoma cell line.SM-7368 (10-25 μM) greatly inhibits TNF-α (20 ng/mL)-induced MMP-9 upregulation. 10 μM of SM-7368 almost completely abrogates this upregulation. Western Blot AnalysisCell Line: HT1080 human fibrosarcoma cellsConcentration:0, 1, 5, 10, 15, 20, and 25 μMIncubation Time:24 hoursResult:Greatly inhibited TNF-α (20 ng/mL)-induced MMP-9 upregulation in a concentration-dependent manner.

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NF-κB Activation Inhibitor III | SM 7368

Apoptosis

NF-κB

D4 receptor

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380623-76-7

328.69

C10H5ClN4O5S

>98% (HPLC)

In Vitro:?DMSO : 83.33 mg/mL (253.52 mM)

[O-][N+](c1cnc(NC(c(cc2)cc(Cl)c2[N+]([O-])=O)=O)s1)=O

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(-20℃)

With Ice Pack

≥ 2 years