TBCA

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TBCA 是一种高选择性 CK2（酪蛋白激酶 II）抑制剂，IC50 = 110 nM，Ki = 77 nM。 TBCA 对 CK2 的选择性优于 CK1、DYRK1A 和一组 27 种其他激酶。

TBCA is a highly selective CK2 (casein kinase II) inhibitor, IC50 = 110 nM, Ki = 77 nM. TBCA shows selectivity for CK2 over CK1, DYRK1A and a panel of 27 other kinases.(In Vitro):TBCA inhibits CK2 double mutant (Val66 Ile174) with an IC50 of 0.68 μM. TBCA (0-100 μM; 24 hours) shows a drastic effect on Jurkat cells viability . TBCA dose-dependently inhibits platelet aggregation and secretion induced by various agonists including CRP, 2-MeSADP, AYPGKF and SFLLRN. TBCA also inhibits phosphorylation of PDK1, Akt, and GSK3β induced by AYPGKF.

TBCA (0-100 μM; 24 hours) shows a drastic effect on Jurkat cells viability.TBCA also inhibits CK2 double mutant (Val66 Ile174) with an IC50 of 0.68 μM.TBCA dose-dependently inhibits platelet aggregation and secretion induced by various agonists including 2-MeSADP, AYPGKF, SFLLRN, and CRP. TBCA also inhibits phosphorylation of PDK1, Akt, and GSK3β induced by AYPGKF. Cell Viability Assay Cell Line:Jurkat cells Concentration:0-100 μM Incubation Time:24 hours Result:The viability of Jurkat cells was reduced.

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Casein Kinase II Inhibitor III, TBCA

Metabolic Enzyme/Protease

Casein Kinase

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934358-00-6

463.74

C9H4Br4O2

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (215.64 mM)

C(=C/C(O)=O)\C1=C(Br)C(Br)=C(Br)C(Br)=C1

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(-20℃)

With Ice Pack

≥ 2 years