AMI-193

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AMI-193 是一种有效的选择性 5-HT2 和 D2 受体拮抗剂，对 5-HT2、D2 受体、5-HT1A、D1 受体和 5-HT1C 受体的 Kis 分别为 2、3、50、2530 和 4300 nM 。

AMI-193 is an effective and selective antagonist of 5-HT2 and D2 receptor with Kis of 2, 3, 50, 2530, and 4300 nM for 5-HT2, D2 Receptor, 5-HT1A, D1 Receptor, and 5-HT1C Receptor. AMI-193 shows antipsychotic activity.(In Vivo):In adult male squirrel monkeys, AMI-193 (0.003 and 0.01 mg/kg; i.m.) decreases the response rate under a fixed-interval (FI) schedule of stimulus termination in a dose-dependent manner and under a second-order schedule of i.v. self-administration of cocaine (0.1 mg/infusion). AMI-193 (0.003 and 0.01 mg/kg; i.m.) attenuates the discriminative-stimulus effects of cocaine.

Spiramide retains affinity for 5-HT1A sites (Ki=50 nM) and also binds at dopamine D2 sites (Ki=3 nM), but possesses low affinity for dopamine D1 sites (Ki=2530 nM).

AMI-193 (0.003-0.01 mg/kg; i.m.) dose-dependently decreases response rate in monkeys under a fixed-interval (FI) schedule of stimulus termination.AMI-193 (0.003-0.01 mg/kg; i.m.) attenuates the discriminative-stimulus effects of cocaine in drug-discrimination experiments.AMI-193 (0.003-0.01 mg/kg; i.m.) reduces response rate under a second-order schedule of i.v. self-administration of cocaine (0.1 mg/infusion). Animal Model:Adult male squirrel monkeys (850-1300 g) Dosage:0.003, 0.01 mg/kg Administration:I.m. on Tuesday, Wednesday, and Thursday the following week Result:Decreased the response rate.The rate-decreasing effects were reversed by cocaine.

Spiramide | Espiramida

GPCR/G Protein

Dopamine Receptor

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510-74-7

383.46

C22H26FN3O2

>98% (HPLC)

In Vitro:?DMSO : 20 mg/mL (52.16 mM)

O=C1NCN(C=2C=CC=CC2)C13CCN(CCCOC4=CC=C(F)C=C4)CC3

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(-20℃)

With Ice Pack

≥ 2 years