AP 18

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

AP 18 是一种选择性 TRPA1 抑制剂。

AP 18 is a selective TRPA1 inhibitor.(In Vitro):At concentrations up to 50 μM, AP-18 is unable to appreciably block activation of TRPV1, TRPV2, TRPV3, TRPV4, or TRPM8. AP-18 reversibly blocks mouse TRPA1 responses to iodoacetamide (an irreversible cysteine-alkylating agent) in CHO cells assayed by ratiometric Ca2+ imaging. AP-18 also blocks cold- and mustard-oil-induced activation of mouse TRPA1. AP-18 blocks cinnamaldehyde-induced TRPA1 currents in excised patches from Xenopus oocytes.(In Vivo):AP18 (1 mM; injected in hindpaw of mice) significantly blocks cinnamaldehdye-induced but not capsaicin-induced nociceptive events, demonstrating efficacy and specificity .

At concentrations up to 50 μM, AP-18 is unable to appreciably block activation of TRPV1, TRPV2, TRPV3, TRPV4, or TRPM8. AP-18 reversibly blocks mouse TRPA1 responses to iodoacetamide (an irreversible cysteine-alkylating agent) in CHO cells assayed by ratiometric Ca2+ imaging. AP-18 also blocks cold- and mustard-oil-induced activation of mouse TRPA1. AP-18 blocks cinnamaldehyde-induced TRPA1 currents in excised patches from Xenopus oocytes.

AP18 (1 mM; injected in hindpaw of mice) significantly blocks cinnamaldehdye-induced but not capsaicin-induced nociceptive events, demonstrating efficacy and specificity.

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Membrane Transporter/Ion Channel

TRP/TRPV Channel

phospholipase A2

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55224-94-7

209.67

C11H12ClNO

>98% (HPLC)

In Vitro:?DMSO : ≥ 100 mg/mL (476.94 mM)

CC(C(C)=CC1=CC=C(Cl)C=C1)=NO

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(-20℃)

With Ice Pack

≥ 2 years