GBR 12783 dihydrochloride

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GBR 12783 diHClide 可改善大鼠的记忆力并增加海马乙酰胆碱的释放。

GBR 12783 dihydrochloride can improve memory performance and increase hippocampal acetylcholine release in rats.GBR 12783 dihydrochloride is a specific, potent and selective dopamine uptake inhibitor that inhibits the [3H]dopamine uptake by rat and mice striatal synaptosomes with IC50s of 1.8 nM and 1.2 nM, respectively.(In Vivo):GBR 12783 (10 mg/kg;?intraperitoneal injection;?for 100 minutes;?male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task.

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GBR 12783 (10 mg/kg; intraperitoneal injection; for 100 minutes; male Sprague-Dawley rats) treatment reinforces specifically dopamine transmission only at synapses instantaneously active, increases hippocampal ACh release and improves memory performance in a passive avoidance task. Animal Model:Male Sprague-Dawley rats (180-200 g) Dosage:10 mg/kg Administration:Intraperitoneal injection; for 100 minutes Result:For a moderate electric shock intensity (0.4 mA), improveed retention performance, increased hippocampal acetylcholine release in vivo.

GBR12783 2HCl

Others

Other Targets

AMPAR

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67469-75-4

485.49

C28H34Cl2N2O

>98% (HPLC)

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Cl.Cl.C(CN1CCN(C\C=C\c2ccccc2)CC1)OC(c1ccccc1)c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years