TUG-424

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TUG-424 在 100 nM 时可显着增强葡萄糖刺激的胰岛素分泌。 TUG-424 是一种有效的选择性游离脂肪酸受体 1 激动剂 (EC50: 32 nM)。

TUG-424 significantly enhances glucose-stimulated insulin secretion at 100 nM. TUG-424 is a potent and selective free fatty acid receptor 1 agonist (EC50: 32 nM).(In Vitro):In the presence of the same glucose concentration, the approximately 2-fold stimulation of secretion by TUG-424 in the presence of 12 mM glucose is comparable to that induced by palmitate. Increasing concentrations (100 nM to 10 μM) of TUG-424 enhances glucose-stimulated insulin secretion significantly already at 100 nM and with a maximal effect at 3 μM. Basal insulin secretion at 2.8 mM glucose is slightly but significantly reduces by TUG-424 .

Increasing concentrations (100 nM to 10 μM) of TUG-424 enhances glucose-stimulated insulin secretion significantly already at 100 nM and with a maximal effect at 3 μM. The approximately 2-fold stimulation of secretion by TUG-424 in the presence of 12 mM glucose is comparable to that induced by palmitate in the presence of the same glucose concentration. Basal insulin secretion at 2.8 mM glucose is slightly but significantly reduces by TUG-424.

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TUG424

Others

Other Targets

Human Endogenous Metabolite

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1082058-99-8

264.324

C18H16O2

>98% (HPLC)

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Cc1ccccc1C#Cc1ccc(CCC(O)=O)cc1

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(-20℃)

With Ice Pack

≥ 2 years