SS-208

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SS-208 是一种选择性 HDAC6 抑制剂 (IC50 = 12 nM)，具有抗肿瘤活性。 SS-208 显示出优于其他 HDAC 亚型的选择性。

SS-208 is a selective inhibitor of HDAC6 (IC50 = 12 nM) with anti-tumor activity. SS-208 shows selectivity over other HDAC subtypes.(In Vivo):In C57BL/6 mice injected immunogenic murine SM1 melanoma cells, SS-208 (25 mg/kg; i.p.) causes a significant reduction of the tumor growth.

——

SS-208 (25 mg/kg, ip) significantly reduces the tumor growth in melanoma murine model. Animal Model:C57BL/6 mice injected immunogenic murine SM1 melanoma cells subcutaneously.Dosage:25 mg/kg.Administration:IP on day 4, 7, 12, 15 and 18.Result:Significantly reduced the tumor growth.

SS208

Cell Cycle/DNA Damage

HDAC

5-HT2

——

——

2245942-72-5

344.15

C13H11Cl2N3O4

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (363.21 mM)

ONC(=O)c1cc(CCNC(=O)c2ccc(Cl)c(Cl)c2)on1

——

(-20℃)

With Ice Pack

≥ 2 years