Progabide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Progabide 是 γ-氨基丁酸受体的激动剂。

Progabide is an agonist of the gamma-aminobutyric acid receptor.(In Vivo):Progabide ( 50, 100 and 200 mg/kg) given IP to male Wistar rats enhance the plasma corticosterone levels by 244, 365, and 476% respectively (t=6.44 to12.55, p<0.01). Progabide (10 mg/kg) fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). Compare with the corresponding control, The greatest corticosterone rise is reached 60 min following the administration of Progabide.

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Progabide is a gamma-aminobutyric acid receptor (GABA) agonist. Doses of 50, 100 and 200 mg/kg Progabide given IP to male Wistar rats increase the plasma corticosterone levels by 244, 365 and 476% respectively (t=6.44 to12.55, p<0.01). 10 mg/kg of Progabide fails to change the concentration of corticosterone in plasma (t=0.76, N.S.). The increased plasma corticosterone level induced by administration of 200 mg/kg Progabide is evident 30 (t=2.625, p<0.05), 60 (t=13.13, p<0.001) and 120 min (t=4.07, p<0.01) after drug injection, but returns to the control value 240 min after drug injection (t=0.86, N.S.). The greatest corticosterone rise (compare with the corresponding control) is reached 60 min following the administration of Progabide.

SL 76002 | Halogabide | Gabren | Gabrene

Others

Other Targets

Kv2.2

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62666-20-0

334.78

C17H16ClFN2O2

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (746.78 mM)

NC(=O)CCC\N=C(\c1ccc(Cl)cc1)c1cc(F)ccc1O

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(-20℃)

With Ice Pack

≥ 2 years