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INDY
CAS No. 1169755-45-6
INDY ( -(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one )
产品货号. M26718 CAS No. 1169755-45-6
INDY 是 Dyrk1A 和 Dyrk1B 的 ATP 竞争性抑制剂，Dyrk1A ATP 口袋的 IC50 分别为 0.24 μM 和 0.23 μM，Ki 为 0.18 μM。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 2MG | ￥347 | 有现货 |
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| 5MG | ￥566 | 有现货 |
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| 10MG | ￥905 | 有现货 |
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| 25MG | ￥1693 | 有现货 |
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| 50MG | ￥2539 | 有现货 |
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| 100MG | ￥3573 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
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| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥592 | 有现货 |
|
生物学信息
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产品名称INDY
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述INDY 是 Dyrk1A 和 Dyrk1B 的 ATP 竞争性抑制剂，Dyrk1A ATP 口袋的 IC50 分别为 0.24 μM 和 0.23 μM，Ki 为 0.18 μM。
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产品描述INDY is an ATP-competitive inhibitor of Dyrk1A and Dyrk1B with IC50s of 0.24 μM and 0.23 μM and a Ki of 0.18 μM for Dyrk1A ATP pocket, respectively.(In Vitro):INDY effectively rescues the repressed NFAT signaling induced by Dyrk1A overexpression. In COS7 cells transfected with either EGFP-Dyrk1A or EGFP-tau, INDY mildly inhibits tau-phosphorylation at the dose of 3 μM, and inhibits nearly completely at the dose of 30 μM.(In Vivo):In the Xenopus embryo, ProINDY (2.5 μM) recoveres normal development apparently.
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体外实验Western Blot Analysis Cell Line:COS7 cells transfected with either EGFP-Dyrk1A and EGFP-tau Concentration:0.3, 1, 3, 10, 30 μM Incubation Time:20 hours Result:Mildly inhibited tau-phosphorylation at 3 μM, and nearly completely inhibited at 30 μM.
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体内实验——
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同义词-(3-ethyl-5-hydroxy-1,3-benzothiazol-2-ylidene)propan-2-one
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通路Others
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靶点Other Targets
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受体GluN1| NMDA receptor
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研究领域——
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适应症——
化学信息
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CAS Number1169755-45-6
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分子量235.3
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分子式C12H13NO2S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : ≥ 33.33 mg/mL (141.65 )
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SMILESCCN1\C(Sc2ccc(O)cc12)=C\C(C)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Issberner JP, Sillar KT. The contribution of the NMDA receptor glycine site to rhythm generation during fictive swimming in Xenopus laevis tadpoles. Eur J Neurosci. 2007 Nov;26(9):2556-64.
