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GT 949
CAS No. 460330-27-2
GT 949 ( —— )
产品货号. M26706 CAS No. 460330-27-2
GT 949 是氨基酸转运蛋白 2 (EAAT2) 的选择性兴奋性正变构调节剂 (EC50: 0.26 nM)。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥259 | 有现货 |
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| 10MG | ￥463 | 有现货 |
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| 25MG | ￥905 | 有现货 |
|
| 50MG | ￥1283 | 有现货 |
|
| 100MG | ￥1872 | 有现货 |
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| 200MG | ￥2691 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥303 | 有现货 |
|
生物学信息
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产品名称GT 949
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GT 949 是氨基酸转运蛋白 2 (EAAT2) 的选择性兴奋性正变构调节剂 (EC50: 0.26 nM)。
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产品描述GT 949 is a selective excitatory positive allosteric modulator of amino acid transporter-2 (EAAT2) (EC50: 0.26 nM).(In Vitro):GT 949 displays selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3. GT 949 improves glutamate transport (EC50 = 0.26 nM) and increases glutamate transport in a non-competitive manner with an increase in Vmax of about 47% in EAAT2-transfected cells.
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体外实验GT 949 (GT949) enhances glutamate transport with an EC50 of 0.26 ± 0.03 nM. GT 949 also demonstrates selectivity to EAAT2 and has no effect on glutamate activity mediated by EAAT1 or EAAT3.GT 949 is also tested for its effect on glutamate uptake kinetics in EAAT2-transfected cells. GT 949 enhances glutamate transport in a noncompetitive fashion, with increase in Vmax of about 47%.
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体5-HT| Dopamine
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研究领域——
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适应症——
化学信息
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CAS Number460330-27-2
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分子量527.673
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分子式C30H37N7O2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 50 mg/mL (94.76 mM)
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SMILESCOc1ccc2[nH]c(=O)c(cc2c1)C(N1CCN(CC1)C1CCCCC1)c1nnnn1CCc1ccccc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Shan-Meng Lin, et al. Structure-Based Stabilization of Non-native Protein-Protein Interactions of Coronavirus Nucleocapsid Proteins in Antiviral Drug Design. J Med Chem. 2020 Mar 26;63(6):3131-3141.
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