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GSK2033
CAS No. 1221277-90-2
GSK2033 ( —— )
产品货号. M26703 CAS No. 1221277-90-2
GSK2033 是 LXR 的拮抗剂（LXRα 或 LXRβ 的 pIC50 分别为 7 和 7.4）。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥820 | 有现货 |
|
| 10MG | ￥1264 | 有现货 |
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| 25MG | ￥2316 | 有现货 |
|
| 50MG | ￥3525 | 有现货 |
|
| 100MG | ￥4851 | 有现货 |
|
| 500MG | ￥9810 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称GSK2033
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述GSK2033 是 LXR 的拮抗剂（LXRα 或 LXRβ 的 pIC50 分别为 7 和 7.4）。
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产品描述GSK2033 is an antagonist of LXR (pIC50s: 7 and 7.4 for LXRα or LXRβ, respectively).(In Vitro):GSK2033 dose-dependently inhibits basal transcription in full-length LXRα or full-length LXRβ cotransfection assays (IC50s: 17 nM and 9 nM, respectively). GSK2033 also effectively inhibits the transcription of an ABCA1 driven luciferase reporter dose-dependently (IC50s: 52 nM for LXRα and 10 nM for LXRβ). GSK2033 also suppresses the expression of both SREBP1 and fatty acid synthase (FASN).(In Vivo):GSK2033 (one month) treatment, does not have obviously effects on hepatic triglyceride levels. GSK2033 treatment also have no effects on plasma triglyceride levels .
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体外实验GSK2033 is a LXR antagonist with pIC50s of 7 and 7.4 for LXRα or LXRβ, respectively. GSK2033 dose-dependently suppresses basal transcription in full-length LXRα or full-length LXRβ cotransfection assays with IC50s of 17 nM and 9 nM, respectively. GSK2033 also effectively suppresses the transcription of an ABCA1 driven luciferase reporter dose-dependently displaying IC50s of 52 nM for LXRα and 10 nM for LXRβ. GSK2033 also suppresses the expression of both of fatty acid synthase (FASN) and SREBP1.
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体内实验One month treatment of GSK2033 does not have significant effects on hepatic triglyceride levels.? Plasma triglyceride levels are also unaffected by treatment with GSK2033.
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同义词——
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通路Others
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靶点Other Targets
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受体——
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研究领域——
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适应症——
化学信息
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CAS Number1221277-90-2
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分子量591.66
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分子式C29H28F3NO5S2
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 30 mg/mL (50.70 mM)
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SMILESCc1cc(C)c(c(C)c1)S(=O)(=O)N(Cc1ccc(o1)C(F)(F)F)Cc1ccc(cc1)-c1cccc(c1)S(C)(=O)=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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Vasoactive Intestina...
Vasoactive Intestinal Constractor [VIC]; Endophilin Beta, Mouse
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Isochiisanoside
Isochiisanoside is a natural product found in the leaves of Acanthopanax chiisanensis NAKAI.
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2-Hydroxychalcone B
2'-Hydroxychalcone is a drug synthesis intermediate for the synthesis of flavonoids. 2'-Hydroxychalcone loaded in nanoemulsion showed fungicidal activity against Coccidioides parapsilosis in Danio rerio model.2'-Hydroxychalcone induced cytotoxicity through oxidative stress in lipid-loaded Hepg2 cells.2'-Hydroxychalcone inhibited the induction of ICAM-1, VCAM-α, tumor necrosis factor-α, and tumor necrosis factor-alpha as determined by reverse transcription-polymerase chain reaction determined by tumor necrosis factor-alpha induces steady-state transcript levels of ICAM-1, VCAM-1, and E-selectin, and therefore may interfere with the transcription of their genes.
