GSK-626616

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GSK-626616 是一种有效的口服生物可利用的 DYRK3 抑制剂 (IC50: 0.7 nM)。它以类似的效力抑制 DYRK 家族的其他成员。 GSK-626616 是治疗贫血的潜在疗法。

GSK-626616 is a potent and orally bioavailable DYRK3 inhibitor (IC50: 0.7 nM). It inhibits other members of the DYRK family with similar potency. GSK-626616 is a potential therapy for the treatment of anemia.(In Vitro):GSK-626616 (serum-deprived HeLa cells) reduces EGF-induced phosphorylation of PRAS40 at Thr246. Binding of PRAS40 to mTORC1 is enhanced by GSK-626616.GSK-626616 abolishes the phosphorylation of S6K1 at Thr389 in nonstimulated HeLa cells. GSK-626616 reduces the phosphorylation of S6K1 at Thr389 in EGF- and insulin-stimulated HeLa cells, showing that mTORC1 activity is impaired.

GSK-626616 abolishes the phosphorylation of S6K1 at Thr389 in nonstimulated HeLa cells. GSK-626616 reduces the phosphorylation of S6K1 at Thr389 in EGF- and insulin-stimulated HeLa cells, showing that mTORC1 activity is impaired.GSK-626616 (serum-deprived HeLa cells) reduces EGF-induced phosphorylation of PRAS40 at Thr246. Binding of PRAS40 to mTORC1 is enhanced by GSK-626616.

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Others

Other Targets

Cereblon| Molecular Glues| TNF-α

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1025821-33-3

401.27

C18H10Cl2N4OS

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (124.60 mM)

Clc1cccc(Cl)c1NC1=NC(=O)\C(S1)=C\c1ccc2nccnc2c1

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(-20℃)

With Ice Pack

≥ 2 years