Glufosinate ammonium

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

草铵膦是谷氨酸的次膦酸类似物，是一种除草剂。草铵膦被植物细胞转化为 PT（L-草胺膦）。

Glufosinate ammonium is a phosphinic acid analogue of glutamic acid and is an herbicide. Glufosinate ammonium is converted by plant cells into PT (L-phosphinothricin). Glufosinate ammonium has neurotoxic activity.(In Vitro):Glufosinate ammonium impairs ependymal cell capability to synthetize cilia. Glufosinate ammonium (1-100 μM; 12DIV) obviously reduces Celsr2 gene expression at 100 μM. Glufosinate ammonium (1-100 μM; 12DIV) disrupts cell-cell adhesion in differentiated V-SVZ neural stem cells (NSCs).(In Vivo):In Wistar rats, Glufosinate ammonium (10-250 mg/kg; gavage; Daily; on days 6-15 of gestation) shows maternal toxicity in the groups given 50 or 250 mg/kg. In male and female rats, the Elimination of Glufosinate ammonium in the blood takes place with a half-life of less than 4 hours.

RT-PCRCell Line: Ependymal cells Concentration:1, 3, 10, 100 μM Incubation Time:During 12DIV (NSCs-to-ependymal cells time point)Result:Significantly decreased Celsr2 gene expression at 100 μM.

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Others

Other Targets

AP-1| CD36| LDL| LOX| NF-κB

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77182-82-2

198.159

C5H15N2O4P

>98% (HPLC)

In Vitro:?H2O : 250 mg/mL (1261.61 mM)

N.CP(O)(=O)CCC(N)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years