F16

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

F16 抑制 neu 过表达细胞的生长和乳腺上皮的增殖。

F16 inhibits the growth of neu-overexpressing cells and the proliferation of mammary epithelial.(In Vitro):F16 arrests the cell cycle and increases apoptosis in F16-sensitive EpH4-A6 cells. F16 (3 μM) influences growth in human and mice cancer cell lines. F16 shows mitochondriotoxic property and triggers apoptosis or necrosis depending on the genetic background of the target carcinoma cell.

F16 (3 μM; 3 days/7 days) affects growth in several mouse and human cancer cell lines.F16 arrests cell cycle and increases apoptosis in F16-sensitive EpH4-A6 cells. Cell Proliferation Assay Cell Line:MDA-MB231, MDA-MB435, MDA-MB436, MDA-MB453, MDA-MB-468, SKBR-3, MCF-7, T47D, ZR-75-1 cells and mouse mammary epithelial cell line NMuMGConcentration:3 μM Incubation Time:3 days/7 days Result:Displayed antiproliferative activity against both mouse and human breast cancer cells. The growth of the mouse fibrosarcoma cell lines derived from ras-transgenic mice was not affected.

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(E)-4-(3-indolylvinyl)-N-methylpyridinium iodide

Others

Other Targets

IGF-1R| P-Akt (S473)| P-Akt (T308)| S6 Kinase

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36098-33-6

362.21

C16H15IN2

>98% (HPLC)

In Vitro:?DMSO : ≥ 31 mg/mL (85.59 mM)

[I-].C[n+]1ccc(\C=C\c2c[nH]c3ccccc23)cc1

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(-20℃)

With Ice Pack

≥ 2 years