Dinoprost

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

地诺前列素是一种天然存在的前列腺素。

Dinoprost is a naturally occurring prostaglandin. It is used in medicine to induce labor and as an abortifacient.(In Vitro):Dinoprost (Prostaglandin F2α; 1 μM; for 24 hours) induces ER stress, autophagy, and apoptosis in goat luteal cells. Dinoprost (1 μM; for 24 hours) significantly increases the expression of GRP78 and UPR sensors.

Apoptosis Analysis Cell Line:Goat luteal cells Concentration:1 μM Incubation Time:For 24 hours Result:Significantly increased the apoptotic rate (15.62±3.12%).Cell Autophagy Assay Cell Line:Goat luteal cells Concentration:1 μM Incubation Time:For 24 hours Result:There was extensive overlap between LC3 and LAMP1 in luteal cells and autophagolysosomes were formed in goat luteal cells.Western Blot Analysis Cell Line:Goat luteal cells Concentration:1 μM Incubation Time:For 24 hours Result:The expression of GRP78 and UPR sensors including cleaved ATF6, phosphorylated-EIF2S1, EIF2S1, ATF4, phosphorylated-IRE1, autophagy-related protein LC3-II, and pro-apoptosis factor cleaved Caspase3 increased significantly in the cells.

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Prostaglandin F2a | PGF2α

Proteasome/Ubiquitin

Endogenous Metabolite

MYC

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551-11-1

354.487

C20H34O5

>98% (HPLC)

In Vitro:?H2O : 100 mg/mL (282.10 mM)

CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)C[C@H](O)[C@@H]1C\C=C/CCCC(O)=O

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(-20℃)

With Ice Pack

≥ 2 years