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Cinanserin hydrochloride
CAS No. 54-84-2
Cinanserin hydrochloride ( SQ 10643 )
产品货号. M26649 CAS No. 54-84-2
Cinanserin Hydrochloride 是 5-HT2 受体的高亲和力拮抗剂 (Ki: 41 nM)，也是严重急性呼吸综合征冠状病毒的 3C 样蛋白酶抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥1254 | 有现货 |
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| 10MG | ￥1862 | 有现货 |
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| 25MG | ￥3227 | 有现货 |
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| 50MG | ￥4641 | 有现货 |
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| 100MG | ￥6219 | 有现货 |
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| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥1036 | 有现货 |
|
生物学信息
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产品名称Cinanserin hydrochloride
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述Cinanserin Hydrochloride 是 5-HT2 受体的高亲和力拮抗剂 (Ki: 41 nM)，也是严重急性呼吸综合征冠状病毒的 3C 样蛋白酶抑制剂。
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产品描述Cinanserin hydrochloride is a high affinity antagonist of the 5-HT2 receptor (Ki: 41 nM) and a 3C-like protease inhibitor of severe acute respiratory syndrome coronavirus.(In Vitro):Cinanserin and Cinanserin hydrochloride inhibit the catalytic activity of SARS-CoV 3CLpro and HCoV-229E 3CLpro (IC50: 4.68 μM and 5.68 μM). Cinanserin/Cinanserin hydrochloride has a binding affinity to SARS-CoV 3CLpro, HCoV-229E 3CLpro, with the KD values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CLpro.(In Vivo):Cinanserin (5 mg/kg; intravenous injection; for 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels.
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体外实验Cinanserin/Cinanserin hydrochloride have binding affinity to SARS-CoV 3CLpro, HCoV-229E 3CLpro, with the KD values of 49.4 μM/78.0 μM for SARS-associated coronavirus (SARS-CoV) 3CLpro and 18.2 μM/36.6 μM for human coronavirus 229E (HCoV-229E) 3CLpro.The IC50 values of Cinanserin and Cinanserin hydrochloride for inhibiting the catalytic activity of SARS-CoV 3CLpro are calculated as 4.92 μM and 5.05 μM, respectively, The corresponding IC50 values for HCoV-229E 3CLpro are 4.68 μM and 5.68 μM. None of the compounds have inhibitory activity against HRV-14 3Cpro at concentrations up to 200 μM.
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体内实验Cinanserin (5 mg/kg; intravenous injection; for 2 hours; male Wistar rats) treatment significantly reduces systemic burn edema to shamburn levels. Leukocyte-endothelial interactions are significantly reduced by administration of Cinanserin. Animal Model:Male Wistar rats (250 g) underwent thermal injury Dosage:5 mg/kg Administration:Intravenous injection; for 2 hours Result:Significantly reduced systemic burn edema to shamburn levels.
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同义词SQ 10643
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通路Microbiology/Virology
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靶点Influenza Virus
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受体aryl hydrocarbon receptor
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研究领域——
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适应症——
化学信息
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CAS Number54-84-2
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分子量376.94
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分子式C20H25ClN2OS
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 125 mg/mL (331.62 mM)
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SMILESCl.CN(C)CCCSc1ccccc1NC(=O)\C=C\c1ccccc1
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
1.Ibabao CN, et al. The AhR agonist VAF347 augments retinoic acid-induced differentiation in leukemia cells. FEBS Open Bio. 2015 Apr 8;5:308-18.
产品手册
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