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CCG-63808
CAS No. 620113-73-7
CCG-63808 ( —— )
产品货号. M26641 CAS No. 620113-73-7
CCG-63808 是 G 蛋白信号传导 (RGS) 蛋白调节剂的可逆抑制剂。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥629 | 有现货 |
|
| 10MG | ￥943 | 有现货 |
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| 25MG | ￥1386 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
生物学信息
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产品名称CCG-63808
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注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
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产品简述CCG-63808 是 G 蛋白信号传导 (RGS) 蛋白调节剂的可逆抑制剂。
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产品描述CCG-63808 is a reversible inhibitor of regulator of G-protein signaling (RGS) proteins. CCG-63808 dose-dependently inhibits the TR-FRET signal between RGS4-AF488 and Tb-Gαo with IC50 values of 1.9 μM.(In Vitro):CCG-63808 showed selectivity among RGS proteins with a potency order of RGS 4 > 19 = 16 > 8 ? 7. CCG-63808 inhibited the GTPase accelerating protein activity of RGS4.
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体外实验——
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体内实验——
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同义词——
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通路Others
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靶点Other Targets
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受体melanocortin 3 (MC3)| melanocortin-1 receptor
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研究领域——
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适应症——
化学信息
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CAS Number620113-73-7
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分子量454.48
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分子式C25H15FN4O2S
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纯度>98% (HPLC)
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溶解度In Vitro:?DMSO : 1 mg/mL (2.20 mM)
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SMILESCc1cccn2c1nc(Oc1ccc(F)cc1)c(\C=C(/C#N)c1nc3ccccc3s1)c2=O
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化学全称——
运输与储存
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储存条件(-20℃)
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运输条件With Ice Pack
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稳定性≥ 2 years
参考文献
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CALP1
Cell-permeable calmodulin (CaM) agonist that binds to the EF-hand/Ca2+-binding site; produces CaM-dependent activation of phosphodiesterase. Also binds to cytoplasmic sites on other Ca2+ channels, including NMDA and HIV-1 gp120-activated channels, inhibiting Ca2+-mediated cytotoxicity and apoptosis (IC50 = 52 μM). Shown to protect pancreatic acinar cells from gossypol induced necrosis. Inhibits VLA-5-mediated adhesion of mast cells to fibronectin in vitro and attenuates inflammatory cell influx in guinea pig lung in vivo.
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Labotest-bb lt000078...
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