UNC6852

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

UNC6852 含有 EED 配体 (IC50 = 247 nM) 和 von Hippel-Lindau 配体，是一种基于 PROTAC 的选择性多梳抑制复合物 2 (PRC2) 降解剂。

UNC6852 contains an EED ligand (IC50 = 247 nM) and a von Hippel-Lindau ligand and is a selective polycomb repressive complex 2 (PRC2) degrader based on PROTAC.(In Vitro):UNC6852 (10 μM; 1-72 hours) results in a decrease in the levels of both EED and EZH2. UNC6852 facilitates PRC2 degradation via VHL recruitment and reduces H3K27me3 levels and DLBCL cell proliferation. UNC6852 displays no cellular toxicity at concentrations up to 30 μM for HeLa Cells.

Cell Proliferation Assay Cell Line:DLBCL Cells Concentration:3 μM Incubation Time:0 -10 days Result:Exhibited anti-proliferative effects.Western Blot AnalysisCell Line:HeLa Cells Concentration:10 μM Incubation Time:1 hours, 4 hours, 8 hours, 10 hours, 16 hours, 20 hours, 24 hours, 48 hours, 72 hours Result:Resulted in a decrease in the levels of both EED and EZH2.

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Cell Cycle/DNA Damage

DNA/RNA Synthesis

Human Endogenous Metabolite

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2688842-08-0

394.42

C22H22N2O5

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (120.05 mM)

CCc(n(Cc1ccccc1)c1ccc2)c(C(C(N)=O)=O)c1c2OCC(OC)=O

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(-20℃)

With Ice Pack

≥ 2 years