ZM223

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ZM223 是 NEDD8 激活酶 (NAE) 的有效非共价抑制剂。

ZM223 is a potent non-covalent inhibitor of NEDD8 activating enzyme (NAE).(In Vitro):ZM223 (0.1-1 μM) inhibits cell growth with IC50s of 100 and 122 nM in HCT-116 and U-2OS cancer cells, respectively. ZM223 (0.1-1 μM) dose-dependently reduces the level of NEDD8 and accumulation of the UBC12 protein thereby reducing the subsequent NEDD8-UBC12 complex.

ZM223 (0.1-1 μM; 4 hours) inhibits both HCT-116 and U-2OS cancer cells with IC50s of 100 and 122 nM, respectively.ZM223 (0.1-1 μM; 4 hours) causes a dose-response decrease in the level of NEDD8 and accumulation of the UBC12 protein, indicating the decrease of the subsequent NEDD8-UBC12 complex.Cell Viability Assay Cell Line:HCT116 colon cancer cells and U-2OS osteosarcoma cells Concentration:0.1 μM, 1 μM Incubation Time:4 hours Result:Inhibited both HCT-116 and U-2OS cancer cells.Western Blot Analysis Cell Line:HCT116 colon cancer cells Concentration:0.1 μM, 1 μM Incubation Time:4 hours Result:Caused a decrease in the level of NEDD8 and an increase in the downstream UBC12 protein.

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ZM-223

Chromatin/Epigenetic

Epigenetic Reader Domain

EGFR

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2031177-48-5

502.53

C23H17F3N4O2S2

>98% (HPLC)

In Vitro:?DMSO : 83.33 mg/mL (165.82 mM)

Nc1ccc(SCC(=O)Nc2ccc3nc(NC(=O)c4ccc(cc4)C(F)(F)F)sc3c2)cc1

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(-20℃)

With Ice Pack

≥ 2 years