ZK824190

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

ZK824190 是一种口服选择性尿激酶纤溶酶原激活剂 (uPA) 抑制剂。

ZK824190 is an orally available and selective inhibitor of urokinase plasminogen activator (uPA). The IC50 values are 237, 1600 and 1850 nM for uPA, tPA, and Plasmin, respectively.(In Vivo):In rats with experimental autoimmune encephalomyelitis (EAE) model, ZK824190 (2?mg/kg; p.o.) exhibited a relatively high oral availability(F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL) and a moderate half time of 2.8 h.

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ZK824190 (2?mg/kg; PO) exhibits a relatively high oral availability and a moderate half time (T1/2=2.8 h). Animal Model:Rats with experimental autoimmune encephalomyelitis (EAE) model Dosage:2?mg/kg (Pharmacokinetic Analysis) Administration:PO Result:Oral availability F?=?55%; Cmax=?0.64?g/mL and AUC?=?2.2?h*g/mL; T1/2=2.8 h.

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Others

Other Targets

5-HT3

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2254001-81-3

414.409

C22H20F2N2O4

>98% (HPLC)

In Vitro:?DMSO : 250 mg/mL (603.28 mM)

CC[C@@H](Oc1nc(Oc2cccc(c2)-c2cccc(CN)c2)c(F)cc1F)C(O)=O

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(-20℃)

With Ice Pack

≥ 2 years