TMPyP4 tosylate

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

TMPyP4 tosylate 是一种四联体特异性配体，是一种端粒酶抑制剂，在骨肉瘤细胞系中具有抗肿瘤作用。

TMPyP4 tosylate is a quadruplex-specific ligand and is a telomerase inhibitor with antitumor effects in osteosarcoma cell lines.

Cell Viability Assay Cell Line:HOS cells Concentration:50? μM Incubation Time:48 or 96 h Result:Time-dependently inhibited cell viability.Western Blot Analysis Cell Line:K562 cells Concentration:100? μM Incubation Time:24 or 48 h Result:Increased the expression of p21CIP1 protein and p57KIP2 protein.

Animal Model:MX-1 mammary chemoadjuvant model Dosage:10 and 20 mg/kg Administration:Intraperitoneal injection (i.p.), twice weekly.Result:Inhibited tumor growth and prolonged mice survival.Animal Model:SARS-CoV-2-infected hamster Dosage:15?mg/kg or 30?mg/kg Administration:i.n., starting at 1?h prior to virus inoculation and continuing until 3 days post infection Result:Decreased the mean viral loads in the nasal wash, nasal turbinate and lung tissues.

TMP 1363

Cell Cycle/DNA Damage

DNA/RNA Synthesis

VHL

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36951-72-1

1363.6

C72H66N8O12S4

>98% (HPLC)

In Vitro:?DMSO : 10 mg/mL (7.33 mM助)

Cc1ccc(cc1)S([O-])(=O)=O.Cc1ccc(cc1)S([O-])(=O)=O.Cc1ccc(cc1)S([O-])(=O)=O.Cc1ccc(cc1)S([O-])(=O)=O.C[n+]1ccc(cc1)-c1c2ccc(n2)c(-c2cc[n+](C)cc2)c2ccc([nH]2)c(-c2cc[n+](C)cc2)c2ccc(n2)c(-c2cc[n+](C)cc2)c2ccc1[nH]2

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(-20℃)

With Ice Pack

≥ 2 years