SK33

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SK33 是一种有效的组织选择性抗雄激素剂。 SK33 降低雄激素受体 (AR) 转录活性。

SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.(In Vitro):SK33 has a significantly potent activity (IC50:0.2 μM) in LNCaPAR+?cells. SK33 decreases cells enter S-phase in LNCaP cells. In LNCaP/BicR cells, increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth(IC50?: 5 μM for SK33).(In Vivo):AR transcriptional activity inhibited by SK33 after 50 mg/kg treatment for 24 hours.

In LNCaPAR+?cells, SK33, demonstrates a significantly potent activity with IC50=0.2 μM. SK33 decreases cells entering S-phase in LNCaP cells.?Treatment of LNCaP/BicR cells with increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth, with IC50?of approximately 5 μM for SK33. Cell Viability Assay Cell Line:LNCaP/BicR cells Concentration:0.1-100 μM Incubation Time:96 hours Result:Results in a dose-dependent response and an inhibition of cell growth.

SK33 (50 mg/kg; s.c.; 24 hours) inhibits AR transcriptional activity. Animal Model:ARE-Luc mice Dosage:50 mg/kg Administration:Subcutaneously; 24 hours Result:Inhibited AR transcriptional activity.

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Endocrinology/Hormones

Androgen Receptor (AR)

5-HT3| α7 nAChR

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1928724-23-5

500.321

C20H13F9N2O3

>98% (HPLC)

In Vitro:?DMSO : 100 mg/mL (199.88 mM)

CC(O)(COc1cc(cc(c1)C(F)(F)F)C(F)(F)F)C(=O)Nc1ccc(C#N)c(c1)C(F)(F)F

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(-20℃)

With Ice Pack

≥ 2 years