SHIN1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

SHIN1 是人丝氨酸羟甲基转移酶 1 (SHMT1) 和人丝氨酸羟甲基转移酶 2 (SHMT2) 的抑制剂，IC50 为 5 nM，IC50 为 13 nM。

SHIN1 is an inhibitor of human serine hydroxymethyltransferse 1(SHMT1) with IC50 of 5 nM and human serine hydroxymethyltransferse 2 (SHMT2) with an IC50 of 13 nM.(In Vitro):SHIN1 inhibits the growth of SHMT2 deletion HCT-116 cells (IC50 = 10 nM). SHIN1 inhibits SHMT1/2 in HCT-116 cells. SHIN1 blocks cell growth through a progressive depletion of purines, leading to loss of nucleotide triphosphates. SHIN1 is particularly active against B-cell malignancies.

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RZ-2994

Others

Other Targets

HMG-CoA reductase

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2146095-85-2

400.482

C24H24N4O2

>98% (HPLC)

In Vitro:?DMSO : 66.67 mg/mL (166.48 mM)

CC(C)C1(c2c(C)n[nH]c2OC(N)=C1C#N)c1cc(CO)cc(c1)-c1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years