RORγt Inverse agonist 6

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

RORγt Inverse agonist 6 是 RORγt inverse 的激动剂。 RORγt 反向激动剂 6 可用于 Th17 驱动的自身免疫性疾病的研究。

RORγt Inverse agonist 6 is an agonist of RORγt inverse. RORγt Inverse agonist 6 can be used in research on Th17-driven autoimmune diseases.(In Vivo):RORγt Inverse agonist 6 (30 mg/kg; p.o.) inhibits the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose. RORγt Inverse agonist 6 suppresses IL-17A gene expression by IL-23 stimulation in a mouse pharmacodynamics model. RORγt Inverse agonist 6 (1 mg/kg; p.o.) exhibits improved drug exposure with AUC of 1289 ng h/mL.

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RORγt Inverse agonist 6 (compound 43) suppresses IL-17A gene expression by IL-23 stimulation in a mouse pharmacodynamics model.RORγt Inverse agonist 6 (compound 43) exhibits improved drug exposure (mouse AUC: 1289 ng?h/mL at 1 mg/kg, po).RORγt Inverse agonist 6 (compound 43, 30 mg/kg, po, b.i.d) inhibits the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose. Animal Model:Mice.Dosage:30 mg/kg.Administration:Orally twice: at 30 min before and 8 h after IL-23 administration.Result:Inhibited the expression level of IL-17A by 59% compared to the vehicle after the oral administration at the tested dose.

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Nuclear Receptor/Transcription Factor

ROR

ADC Linker

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1887161-80-9

565.03

C28H29ClN6O5

>98% (HPLC)

In Vitro:?DMSO : 50 mg/mL (88.49 mM)

CC(C)n1c2ccc(NC(=O)N3CCO[C@H](C3)C(=O)Nc3ccc(C#N)c(Cl)c3)cc2c(=O)n(CC2CC2)c1=O

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(-20℃)

With Ice Pack

≥ 2 years