PI3K/mTOR Inhibitor-2

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

PI3K/mTOR Inhibitor-2 是一种有效的 PI3K 和 mTOR 泛抑制剂，对 PI3Kα、PI3Kβ、PI3Kδ、PI3Kγ 和 mTOR 的 IC50 分别为 3.4、34、16,1 和 4.7 nM。 PI3K/mTOR Inhibitor-2 具有抗肿瘤活性。

PI3K/mTOR Inhibitor-2 is a potent pan inhibitor of PI3K and mTOR with IC50s of 3.4, 34, 16,1 and 4.7 nM for PI3Kα, PI3Kβ, PI3Kδ, PI3Kγ and mTOR. PI3K/mTOR Inhibitor-2 has antitumor activity.(In Vitro):PI3K/mTOR Inhibitor-2 exhibited high enzyme activity against PI3K and mTOR, potent suppression of Akt and p70s6k phosphorylation with IC50s of 11.6 and 89.2 nM in cell assays, and good pharmacokinetic profile.(In Vivo):PI3K/mTOR Inhibitor-2 demonstrated in vivo efficacy in a PC-3M tumor xenograft model.

PI3K/mTOR Inhibitor-2 (Compound 31) inhibits p-AKT and p-p70s6k in MCF-7 cells with IC50s of 11.6 and 89.2 nM, respectively.

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PI3K/Akt/mTOR signaling

PI3K

HMG-CoA reductase

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1848242-58-9

478.85

C20H13ClF2N4O4S

>98% (HPLC)

In Vitro:?DMSO : 8.33 mg/mL (17.40 mM)

COc1ncc(cc1NS(=O)(=O)c1ccc(F)cc1F)-c1ccc2ncc(Cl)c(=O)n2c1

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(-20℃)

With Ice Pack

≥ 2 years