Oxotremorine M iodide

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Oxotremorine M iodide 是一种有效的非选择性毒蕈碱乙酰胆碱受体 (mAChR) 激动剂。

Oxotremorine M iodide is a potent and non-selective agonist of muscarinic acetylcholine receptor (mAChR).(In Vitro):Oxotremorine M iodide robustly elicits a phosphoinositide response (EC50 = 0.22 μM).?Oxotremorine M iodide shows EC50s of 0.36, 0.52, 1.62, and 1.48 μM for wild-type, M2, M3, and M2/M3 knockout mice, respectively.?Oxotremorine M iodide (0.1-30 μM) dose-dependently inhibits KCNQ2/3 currents.(In Vivo):In male Sprague-Dawley albino rats, Oxotremorine M iodide (0.5 mg/kg; s.c.) increases DA release in the medial prefrontal cortex without affecting the nucleus accumbens.

Oxotremorine M iodide (0.1, 0.3, 1, 3, 10, 30 μM) inhibits KCNQ2/3 currents in the concentration-dependence. Oxotremorine M iodide elicits a robust phosphoinositide response characterized with an EC50 of 0.22 μM. Oxotremorine M iodide has EC50s of 0.36, 0.52, 1.62, and 1.48 μM for wild-type, M2, M3, and M2/M3 knockout mice, respectively.

Oxotremorine M iodide (0.5 mg/kg; s.c.) increases Ddopamine (DA) release in the medial prefrontal cortex (mPFC) and has no effect in the nucleus accumbens (NAC) in male sprague-dawley albino rats weighing 250-350 g.

Oxotremorine methiodide

Others

Other Targets

5-HT1| 5-HT2| 5-HT4

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3854-04-4

322.19

C11H19IN2O

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (387.97 mM)

[I-].C[N+](C)(C)CC#CCN1CCCC1=O

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(-20℃)

With Ice Pack

≥ 2 years