OMDM-1

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

OMDM-1 是一种选择性且代谢稳定的 anandamide 细胞摄取 (ACU) 抑制剂，Ki 为 2.4 μM。

OMDM-1 is a selective and metabolically stable anandamide cellular uptake (ACU)inhibitor with a Ki of 2.4 μM.(In Vitro):OMDM-1 is anovel potent and selective inhibitors of ACU?and one "hybrid" agonist of CB(1) and VR1 receptors (OMDM-6).?Unlike other compounds of the same type, OMDM-1, OMDM-2, and OMDM-6 were very stable to enzymatic hydrolysis by rat brain homogenates.The (R)- and, particularly, the (S)-1'-(4-hydroxybenzyl) derivatives of N-oleoylethanolamine and AEA (OMDM-1, OMDM-2, OMDM-3, and OMDM-4) inhibited to a varied extent ACU in RBL-2H3 cells (K(i) ranging between 2.4 and 17.7 micro M), the oleoyl analogues (OMDM-1 and OMDM-2, K(i) 2.4 and 3.0 micro M, respectively) being 6- to 7-fold more potent than the arachidonoyl analogues (OMDM-3 and OMDM-4). .

OMDM-1 shows poor affinity for either CB1 (Ki=12.1 μM) or CB2 (Ki>10 μM) receptors in rat brain and spleen membranes, respectively; OMDM-1 has almost no activity at vanilloid receptors in the intracellular calcium assay carried out with intact cells over-expressing the human VR1 (EC50≥10 μM), and no activity as inhibitors of FAAH in N18TG2 cell membranes (Ki>50 μM).

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(Z)-N-[(2S)-1-hydroxy-3-(4-hydroxyphenyl)propan-2-yl]octadec-9-enamide

Proteasome/Ubiquitin

Endogenous Metabolite

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616884-62-9

431.661

C27H45NO3

>98% (HPLC)

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CCCCCCCC\C=C/CCCCCCCC(=O)N[C@H](CO)Cc1ccc(O)cc1

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(-20℃)

With Ice Pack

≥ 2 years