Benzyl-α-GalNAc

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

Benzyl-α-GalNAc 是一种有效的 O-糖基化抑制剂，用于减少细胞表面的粘蛋白。

Benzyl-α-GalNAc is a potent inhibitor of O-glycosylation and is used to reduce mucin on cell surfaces.

Cell Viability Assay Cell Line:SUIT-2 cells Concentration:5 mM Incubation Time:72 h Result:Inhibited mucin O-glycosylation.Cell Viability Assay Cell Line:LX-2 cellsConcentration:2, 4 mM Incubation Time:48 h Result:Remarkably decreased the expression of α-SMA in a dose-dependent manner (α-SMA is the marker for the activation of HSCs, which means that quiescent cells transform into myofibroblasts).Cell Proliferation Assay Cell Line:LX-2 cells (PDGF-BB-induced)Concentration:2, 4 mM Incubation Time:48 h Result:Partly reversed PDGF-BB-induced proliferation in cells.Western Blot Analysis Cell Line:LX-2 cells Concentration:2, 4 mM Incubation Time:48 h Result:Downregulated the mRNA levels of collagens I and III in a dose-dependent manner.

Animal Model:Female severe combined immunodeficient (SCID) mice (6 to 8-week-old; capan-1 tumour model).Dosage:1 mg/mice (in combination with 5-FU)Administration:Tumoural injection; single daily; days 4, 6, 8 and 10 after tumour size reaches 50-70 mm3 Result:Significantly lowered neoplastic cells compared to 5-FU alone.

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Others

Other Targets

Human Endogenous Metabolite

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3554-93-6

311.334

C15H21NO6

>98% (HPLC)

In Vitro:?DMSO : 25 mg/mL (80.30 mM)

CC(=O)N[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1OCc1ccccc1

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(-20℃)

With Ice Pack

≥ 2 years