N-(2-Chloro-6-methylphenyl)-N-4-pyridinylurea

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

N-(2-Chloro-6-methylryl)-N'-4-pyridinylurea 是一种抗惊厥药，可治疗全身性强直阵挛和部分性癫痫发作。

N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea is an anticonvulsant agent, treatment of generalized tonic-clonic and partial seizures.(In Vivo):N-(2-Chloro-6-methylphenyl)-N'-4-pyridinylurea shows anticonvulsant activity at 30 mg/kg in the initial tests with no signs of ataxia until 300 mg/kg.?The activity seen with 30 mg/kg 37 is still present 4 h postdose.?Compound is effective against seizures induced by maximal electroshock but does not protect mice from clonic seizures produced by the convulsant pentylenetetrazol.?The overall pharmacological profile suggests that Compound would be of therapeutic use in the treatment of generalized tonic-clonic and partial seizures.

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Compound shows anticonvulsant activity at 30 mg/kg in the initial tests with no signs of ataxia until 300 mg/kg. The activity seen with 30 mg/kg 37 is still present 4 h postdose. Compound is effective against seizures induced by maximal electroshock but does not protect mice from clonic seizures produced by the convulsant pentylenetetrazol. The overall pharmacological profile suggests that Compound would be of therapeutic use in the treatment of generalized tonic-clonic and partial seizures. Compound is selected for clinical trials.

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Others

Other Targets

nAChR| PAFR

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97627-24-2

261.71

C13H12ClN3O

>98% (HPLC)

In Vitro:?DMSO : 125 mg/mL (477.63 mM)

Cc1cccc(Cl)c1NC(=O)Nc1ccncc1

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(-20℃)

With Ice Pack

≥ 2 years