GNE-1858

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

GNE-1858 是一种 ATP 竞争性造血祖激酶-1 (HPK1) 抑制剂（野生型和活性模拟突变体 HPK1-TSEE 和 HPK1-SA 的 IC50 分别为 1.9 nM、1.9 nM 和 4.5 nM）。

GNE-1858 is an ATP-competitive hematopoietic progenitor kinase-1 (HPK1) inhibitor (IC50s of 1.9 nM, 1.9 nM, and 4.5 nM for wild-type and the active mimetic mutants HPK1-TSEE and HPK1-SA).(In Vitro):HPK1 is a negative-feedback regulator of T cell receptor signaling, which dampens T cell proliferation and effector function.Hematopoietic progenitor kinase-1 (HPK1), a serine/threonine Ste20-related protein kinase whose expression is restricted to the hematopoietic compartment (e.g., T cells, B cells, and dendritic cells), is one such kinase.?

Hematopoietic progenitor kinase-1 (HPK1), a serine/threonine Ste20-related protein kinase whose expression is restricted to the hematopoietic compartment (e.g., T cells, B cells, and dendritic cells), is one such kinase. HPK1 is a negative-feedback regulator of T cell receptor signaling, which dampens T cell proliferation and effector function.

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Others

Other Targets

5-HT6

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2680616-96-8

428.492

C21H26F2N8

>98% (HPLC)

In Vitro:?DMSO : 20 mg/mL (46.68 mM)

CC(C)n1ncc2cnc(Nc3cc(nc(n3)N3CCC(F)(F)C3)C3CCNC3)cc12

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(-20℃)

With Ice Pack

≥ 2 years