021-51111890
购物车（）
sales@molnova.cn
EMT inhibitor-1
CAS No. 1638526-21-2
EMT inhibitor-1 ( —— )
产品货号. M26197 CAS No. 1638526-21-2
EMT抑制剂-1是Hippo、Wnt信号传导和TGF-巨噬细胞(TGF-)的抑制剂，具有抗肿瘤活性。
纯度: >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| 规格 | 价格/人民币 | 库存 | 数量 |
| 5MG | ￥2679 | 有现货 |
|
| 10MG | ￥4256 | 有现货 |
|
| 25MG | ￥6445 | 有现货 |
|
| 50MG | ￥8677 | 有现货 |
|
| 100MG | ￥11340 | 有现货 |
|
| 500MG | 获取报价 | 有现货 |
|
| 1G | 获取报价 | 有现货 |
|
| 1 mL x 10 mM in DMSO | ￥2822 | 有现货 |
|
生物学信息
-
产品名称EMT inhibitor-1
-
注意事项本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
-
产品简述EMT抑制剂-1是Hippo、Wnt信号传导和TGF-巨噬细胞(TGF-)的抑制剂，具有抗肿瘤活性。
-
产品描述EMT inhibitor -1 is an inhibitor of Hippo, Wnt signaling and TGF- macrophages (TGF-) with antitumor activity.(In Vitro):EMT inhibitor-1 (C19) inhibiting cancer cell migration, proliferation, and resistance to doxorubicin in vitro.EMT inhibitor-1 (C19) (0-10μM; 24 hours) is an inhibitor of of Hippo, TGF-β, and Wnt signaling pathways with antitumor activities.(In Vivo):EMT inhibitor-1 (C19) (intraperitoneal injection;?5-20 mg/kg) exerts strong antitumor activity in a mouse tumor model.?Mechanistically, EMT inhibitor-1 induces GSK3-β–mediated degradation of the Hippo transducer TAZ, through activation of the Hippo kinases Mst/Lats and the tumor suppressor kinase AMPK upstream of the degradation complex.C19 is dissolved in the vehicle solution (100 μL of DMEM containing 5% dimethyl sulfoxide).
-
体外实验——
-
体内实验——
-
同义词——
-
通路Wnt/Notch/Hedgehog
-
靶点Wnt/beta/catenin
-
受体PDE4| PDE5
-
研究领域——
-
适应症——
化学信息
-
CAS Number1638526-21-2
-
分子量319.2
-
分子式C12H12Cl2N2O2S
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 100 mg/mL (313.27 mM)
-
SMILESOCCCCOc1nsnc1-c1ccc(Cl)c(Cl)c1
-
化学全称——
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Nagendran J, et al. Phosphodiesterase type 5 is highly expressed in the hypertrophied human right ventricle, and acute inhibition of phosphodiesterase type 5 improves contractility. Circulation. 2007 Jul 17;116(3):238-48.
产品手册
关联产品
-
Wnt pathway inhibito...
Wnt pathway inhibitor 3 是一种有效的 AC1 抑制剂，IC50 值为 45 nM。Wnt pathway inhibitor 3 具有抗增殖活性。
-
YW2036
YW2036 (compound 2a) 是一种有效的 Wnt/β-Catenin 信号通路抑制剂，IC50 值为 637 nM。YW2036 可用于癌症研究。
-
Carboxylesterase-IN-...
Carboxylesterase-IN-2 (compound 4u) 是一种有效的 Carboxylesterase Notum 抑制剂，IC50 小于或等于 10 nM。Notum 是 Wnt 信号传导的负调节剂，通过棕榈油酸酯的水解作用，这是 Wnt 活性所必需的。Carboxylesterase-IN-2具有研究癌症疾病的潜力。
