EB-47

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

EB-47 模拟底物 NAD+，并从烟酰胺延伸至腺苷亚位点。EB-47 是一种有效的选择性 PARP-1/ARTD-1 抑制剂，IC50 值为 45 nM。

EB-47 mimics the substrate NAD+ and extends from the nicotinamide to the adenosine subsite.EB-47, a potent and selective PARP-1/ARTD-1 inhibitor with an IC50 value of 45 nM, shows modest potency against ARTD5 with an IC50 value of 410 nM.(In Vitro):The inhibitory effect of EB-47 on CdPARP and HsPARP was 0.86 and 1.0uM with IC50 value respectively, and the inhibitory effect on CdPARP was over 50%.(In Vivo):EB-47 (2 μM;?5 days) decreases the number of embryo implantation sites and blastocysts at day 5.PARP1 participates in the process of embryo implantation.

EB-47 shows inhibition in excess of 50% with CdPARP, and it is able to inhibit CdPARP and HsPARP with IC50 values of 0.86 and 1.0?μM, respectively.

EB-47 (2 μM; 5 days) decreases the number of embryo implantation sites and blastocysts at day 5. PARP1 participates in the process of embryo implantation.

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Others

Other Targets

5-HT1A| 5-HT2A| D2 receptor

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366454-36-6

537.537

C24H27N9O6

>98% (HPLC)

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Nc1ncnc2n(cnc12)[C@@H]1O[C@@H]([C@@H](O)[C@H]1O)C(=O)N1CCN(CC(=O)Nc2cccc3C(=O)NCc23)CC1

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(-20℃)

With Ice Pack

≥ 2 years