DOV-216,303 Free Base

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

DOV-216,303 Free Base 是一种血清素、去甲肾上腺素和多巴胺再摄取抑制剂，IC50 分别为 14、20 和 78 nM。

DOV-216,303 Free Base is an inhibitor of serotonin, norepinephrine, and dopamine reuptake with with IC50s of 14, 20 and 78 nM. DOV-216,303 Free Base exhibits antidepressant effects.(In Vivo):In male Sprague Dawley rats of OBX or Sham surgery, DOV 216,303 (20 mg/kg; i.p.; choronic) increases extracellular concentrations of dopamine, norepinephrine and serotonin and significantly increases extracellular baseline serotonin concentrations while DOV-216,303 (20 mg/kg; i.p.; acute) significantly increases dopamine, norepinephrine and serotonin levels.

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Acute treatment of DOV-216,303 (20 mg/kg, i.p.) significantly increases dopamine, norepinephrine and serotonin levels in both OBX and Sham animals.Chronic treatment with DOV 216,303 (20 mg/kg, i.p., for 17 days) increases extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increases extracellular baseline serotonin concentrations. Animal Model:Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery.Dosage:20 mg/kg.Administration:I.P. daily for 17 days.Result:Increased extracellular concentrations of dopamine, norepinephrine and serotonin in the medial prefrontal cortex of both OBX and Sham animals and significantly increased extracellular baseline serotonin concentrations.Animal Model:Male Sprague Dawley rats weighing between 290 and 350 g at time of OBX or Sham surgery.Dosage:20 mg/kg.Administration:I.P. once.Result:Significant increases in dopamine, norepinephrine and serotonin levels were measured in both OBX and Sham animals.

DOV-216303

GPCR/G Protein

Dopamine Receptor

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66504-40-3

228.12

C11H11Cl2N

>98% (HPLC)

In Vitro:?DMSO : ≥ 125 mg/mL (547.96 mM)

Clc1ccc(cc1Cl)C12CC1CNC2

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(-20℃)

With Ice Pack

≥ 2 years