CDDO-EA ( CDDO ethyl amide | TP319 | RTA 405 )

产品货号. M26099 CAS No. 932730-51-3

CDDO-EA 是 Nrf2/抗氧化反应元件的激活剂。

纯度: >98% (HPLC)

COA

Datasheet

HNMR

HPLC

MSDS

Handing Instructions

规格	价格/人民币	库存	数量
5MG	￥1644	有现货
10MG	￥2993	有现货
25MG	￥4622	有现货
50MG	￥6501	有现货
100MG	￥8478	有现货
200MG	￥11430	有现货
500MG	获取报价	有现货
1G	获取报价	有现货
1 mL x 10 mM in DMSO	￥1891	有现货

产品询价大包装询价加入购物车

生物学信息

产品名称

CDDO-EA
注意事项

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断
产品简述

CDDO-EA 是 Nrf2/抗氧化反应元件的激活剂。
产品描述

CDDO-EA is an activator of the Nrf2/antioxidant response element.(In Vitro):In a cell culture model of ALS, CDDO-EA potently activates Nrf2/ARE . CDDO-EA induces apoptosis in A549 lung cancer cells and induces heme oxygenase-1. CDDO-EA is 7-fold more potent than CDDO as a suppressor of the ability of IFN-γ to induce iNOS in RAW264.7 macrophage-like cells.(In Vivo):CDDO-EA-treated G93A mice live significantly longer than the control. CDDO-EA increases the life-span from 124.05 days to 144.72 days (16.6%). In CDDO-EA-treated G93A mice, the age of death is 141.4 days and the duration from the age of onset to the age of death is 57.6 days. The age of death from the onset is prolonged by 17.5 days (43%) .
体外实验

CDDO-EA potently activates Nrf2/ARE in a cell culture model of ALS and in the G93A SOD1 mouse model of ALS. CDDO-EA is a potent inducer of apoptosis in A549 lung cancer cells, as shown both by PARP cleavage and Annexin staining. CDDO-EA is more potent than CDDO itself as inducers of heme oxygenase-1 (HO-1). In RAW264.7 macrophage-like cells, CDDO-EA is 7-fold more potent than CDDO as suppressors of the ability of IFN-γ to induce iNOS.
体内实验

The survival analysis shows that G93A mice treated with CDDO-EA, compared to G93A littermate controls, lives significantly longer. CDDO-EA treatment increases the life-span by 20.6 days from 124.05±3.7 days to 144.72±8.1 days (16.6%) (p<0.001). In CDDO-EA-treated G93A mice, the age of death is 141.4±5.2 days and the duration from the age of onset to the age of death is 57.6±7.6 days, which means that the age of death from onset is prolonged by 17.5 days (43%).
同义词

CDDO ethyl amide | TP319 | RTA 405
通路

Nuclear Receptor/Transcription Factor
靶点

Keap1-Nrf2
受体

E3 Ligase Ligand-Linker Conjugate
研究领域

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适应症

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化学信息

CAS Number

932730-51-3
分子量

518.73
分子式

C33H46N2O3
纯度

>98% (HPLC)
溶解度

In Vitro:?DMSO : 16.67 mg/mL (32.14 mM)
SMILES

C(NCC)(=O)[C@]12[C@]([C@@]3([C@@](C)(CC1)[C@@]4(C)C(=CC3=O)[C@]5(C)[C@@](CC4)(C(C)(C)C(=O)C(C#N)=C5)[H])[H])(CC(C)(C)CC2)[H]
化学全称

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