Arazine

本公司产品仅用于科研实验，不得用于人体或动物的临床与诊断

通过与异戊二烯化 G 蛋白或其受体位点竞争，阿拉嗪可以成为异戊二烯半胱氨酸甲基转移酶的底物。 Arazine 是 G 蛋白和 GPCR 信号传导的细胞渗透性调节剂。

Arazine can be a a substrate for isoprenylcysteine methyltransferase by competing with prenylated G protein or its receptors site. Arazine is a cell-permeable modulator of G protein and GPCR signaling.(In Vitro):Arazine (10–100 μM; 8h) significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion in HMEC-1 cell. Arazine (2h) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner in HMEC-1 cell.(In Vivo):Arazine (2,000 μg/20 μl) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with an ED50 of 55 μg/20 μl.

Arazine (2 hours) inhibits ATPγS induced CXCL1, CXCL8 and CCL2 production as a dose-dependent manner inHMEC-1 cell.Arazine (10–100 μM;8 hours)significantly affects the HMEC-1 cell viability as measured by trypan blue exclusion inHMEC-1 cell.

Arazine (AFC) (2,000?μg/20?μl; applied on ear) produces a dose-dependent inhibition of the TPA-induced edema, with the maximal reduction of edema approaching 73%, with a 50% effective dose (ED50) of 55±12?μg/20?μl. Animal Model:TPA-induced ear acute inflammation in mouse Dosage:2000?μg/20?μl Administration:2000?μg/20?μl; Applied on ear Result:Inhibited ear edema, as measured by ear weight.

N-Acetyl-S-farnesyl-L-cysteine

Others

Other Targets

S1PR4

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135304-07-3

367.55

C20H33NO3S

>98% (HPLC)

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O=C(O)[C@H](CSC/C=C(C)/CC/C=C(C)/CC/C=C(C)\C)NC(C)=O

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(-20℃)

With Ice Pack

≥ 2 years